Synthesis, Characterization, and Antimicrobial Studies of Chalcone Derived Schiff bases

Gan, Juan Zheng (2018) Synthesis, Characterization, and Antimicrobial Studies of Chalcone Derived Schiff bases. Final Year Project (Bachelor), Tunku Abdul Rahman University College.

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Abstract

Three Schiff bases of N-phenylthiosemicarbazide with 4-substituted chalcone (OCH3, Cl and NO2) analogues have been synthesized successfully. The characterization methods that have been done including melting points test, Fourier Transform Infrared spectroscopy, Ultraviolet–visible spectroscopy, Proton (1H) nuclear magnetic resonance and also Carbon-13 nuclear magnetic resonance. The antimicrobial activities of the synthesized Schiff bases were evaluated against the bacteria Staphylococcus, Escherichia coli and Pseudomonas by the agar disk-diffusion method. Staphylococcus is a Gram positive bacteria, while Escherichia coli and Pseudomonas are Gram negative bacteria. All the synthesized Schiff bases exhibited a better inhibition activity towards Staphylococcus as compared with another two bacteria. Synthesized Schiff bases exhibited stronger inhibitory activities as compared to their raw materials. The PT4MX exhibited the highest antimicrobial activity as compared to the rest of Schiff bases and positive control in the inhibition of Staphylococcus bacteria.