Synthesis, Characterization, and Antimicrobial Studies of Chalcone Derived Schiff bases



Gan, Juan Zheng (2018) Synthesis, Characterization, and Antimicrobial Studies of Chalcone Derived Schiff bases. Final Year Project (Bachelor), Tunku Abdul Rahman University College.

[img] Text
Gan Juan Zheng_Full Text.pdf
Restricted to Registered users only

Download (1MB)


Three Schiff bases of N-phenylthiosemicarbazide with 4-substituted chalcone (OCH3, Cl and NO2) analogues have been synthesized successfully. The characterization methods that have been done including melting points test, Fourier Transform Infrared spectroscopy, Ultraviolet–visible spectroscopy, Proton (1H) nuclear magnetic resonance and also Carbon-13 nuclear magnetic resonance. The antimicrobial activities of the synthesized Schiff bases were evaluated against the bacteria Staphylococcus, Escherichia coli and Pseudomonas by the agar disk-diffusion method. Staphylococcus is a Gram positive bacteria, while Escherichia coli and Pseudomonas are Gram negative bacteria. All the synthesized Schiff bases exhibited a better inhibition activity towards Staphylococcus as compared with another two bacteria. Synthesized Schiff bases exhibited stronger inhibitory activities as compared to their raw materials. The PT4MX exhibited the highest antimicrobial activity as compared to the rest of Schiff bases and positive control in the inhibition of Staphylococcus bacteria.

Item Type: Final Year Project
Subjects: Science > Chemistry
Faculties: Faculty of Applied Sciences > Bachelor of Science (Honours) in Analytical Chemistry
Depositing User: Library Editor
Date Deposited: 28 Mar 2019 08:08
Last Modified: 15 Apr 2022 03:33