Alleviation of Psoriasis Using Nigella Sativa

Ellaheebucksh, Umme Wardah Siddiqah (2021) Alleviation of Psoriasis Using Nigella Sativa. Final Year Project (Bachelor), Tunku Abdul Rahman University College.

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Abstract

Psoriasis is a chronic, hyperproliferative, inflammatory skin disease that affects about 1%–3% of the world's population. Psoriasis involves diverse interactions between immune cells, keratinocytes, and other skin-resident cells. The production of herbal medicines has been fueled by the demand for alternative and effective anti-psoriatic agents due to relapse and adverse drug effects with conventional therapies. The available literature on the effectiveness of herbal medicine against keratinocytes (HaCaT cells) for the treatment of psoriasis in vitro via anti-proliferative assays was compared. Nigella sativa, also known as black seed, has been used as a natural remedy throughout the world. It has a wide range of pharmacological activity, including anti-inflammatory, immunostimulatory, and antioxidant properties. The previously reported chemical constituents present in the black seed which were compared using SDS-PAGE, GC-MS, HPLC and FTIR analysis. Thymoquinone was found to be the main active ingredient in Nigella sativa (NS) volatile oil. The objective of this study was to review the anti-psoriatic properties of NS based on the previously published in vitro, in vivo and clinical studies. Study reported that the 95 % ethanolic extract of NS showed strong antiproliferative activity when compared to asiaticoside. The NS gel developed a large degree of orthokeratosis (71.36±2.64%), which was comparable to the regular tazarotene gel (90.03±2.00%) and topical application of black seed oil significantly reduced Imiquimodinduced psoriasis-like inflammation and reversed both epidermal and dermal changes. In 85 % of patients, a combination of NS ointment and oral doses resulted in complete cure of lesions and 10 of 12 patients treated with a natural preparation containing NS extract showed treatment success with a PASI reduction of at least 75%. Moreover, a case report of refractory psoriatic arthritis achieving remission using NS was highlighted. In conclusion, Nigella sativa has good antipsoriatic activity due to the display of promising results from previously published researched articles, therefore, it can help in managing psoriasis.