The Efficacy and Specificity of 3-Methoxy-N-(Methylcarbamothioyl)Benzamide on CU2+ Ion Detection

Lim, Wen Qian (2024) The Efficacy and Specificity of 3-Methoxy-N-(Methylcarbamothioyl)Benzamide on CU2+ Ion Detection. Final Year Project (Bachelor), Tunku Abdul Rahman University of Management and Technology.

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Abstract

The Chemosensor, 3-methoxy-N-(methylcarbamothioyl)benzamide with high selectivity towards Cu2+ ions and a detection limit of 6.139 × 10-6 M, which has an immediate response time has been synthesized and characterized by using FTIR Spectroscopy, Melting Point Apparatus, DSC, CHNS Elemental Analyzer, UV-Vis Spectroscopy, 1H NMR and 13C NMR. The results only includes experimental studies. The chemosensor, 3-methoxy-N-(methylcarbamothioyl)benzamide has an immediate response time when detecting Cu2+ ions. When the ligand is added into the Cu2+ salt solution by using methanol as a solvent, its colour changes from blue to green while forming a metal-complex solution. However, the ligand, 3-methoxy-N-(methylcarbamothioyl)benzamide does not show any colour changes after adding into Fe2+, Fe3+, Cu2+, Co2+, Mg2+, Sn2+, Zn2+ and Ni2+. Subsequently, these metal-complex solution and metal-ligand solution are analysed using UV-Vis Spectroscopy to detect any changes in the spectrum when compared to the spectrum of the ligand itself. An additional peak at 377.5 nm was detected for the metal-complex solution formed by using the ligand and Cu2+ ions. The detection limit of the ligand, 3-methoxy-N-(methylcarbamothioyl)benzamide was also determined by using a series of decreasing concentration solution, which is 6.139 × 10-6 M. Last but not least, the chemical structure of the metal-complex formed by the ligand, 3-methoxy-N-(methylcarbamothioyl)benzamide and Cu2+ ions has been predicted by using the Job’s Plot with the help of UV-Vis Spectroscopy and the shift of the absorption band of the functional group of the ligand with the help of FTIR-Spectroscopy. The predicted metal-complex is found out have a 1:1 ratio of [Ligand]:[Cu2+] and the coordinate bonding form (binding site) is at the position of the nitrogen atoms of the ligand.