Transient Analysis of Air-Puff-Induced Corneal Deformation by Ocular Response Analyzer

Yap, Kok Chee (2020) Transient Analysis of Air-Puff-Induced Corneal Deformation by Ocular Response Analyzer. Final Year Project (Bachelor), Tunku Abdul Rahman University College.

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Abstract

Glaucoma is one of the leading causes of blindness. Biomechanical properties such as intraocular pressure (IOP), central corneal thickness (CCT), and more are often associated with glaucoma. Ocular Response Analyzer (ORA) by Reichert is a device that is capable of measuring the IOP, CCT of the eye. However, the treatment of glaucoma remains unknown due to the lack of resources available. Besides that, the knowledge on the treatment of glaucoma has yet to be fully explored because of the complexity of the structure of the eye. This study simulates a fluidstructure interaction model between a human eye modeled with linear elastic properties and an air-puff to understand the effects of the linear elastic properties of the eyes on the corneal deformation caused by the air-puff. The effects of each parameter on corneal deformation are observed from the change in the magnitude of the maximum corneal deformation and stress before and after altering the parameters. In total, there are four parameters with 20 input values (five input values each parameter). The simulation is performed by altering the value of input IOP (12, 15, 18, 21, and 24 mmHg), CCT (508, 533, 558, 583, and 608 μm), elastic modulus of cornea, EC (1.2, 1.35, 1.5, 1.65, and 1.8 MPa), and elastic modulus of sclera, ES (1.5, 2.25, 3, 3.75, and 4.5 MPa). The increased in these parameters correlates to the decreased maximum corneal deformation and stress. It is found that in the results the elastic modulus of sclera, ES plays a minimal role in corneal deformation. The decreased in the corneal apex deformation and stress are associated with the increase in the corneal deformation resistance and stress resistance. The parameters, results and application of the simulation are validated by multiple different existing journals.